Senior Research Investigator

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Posted Job Title

Senior Research Investigator

Job Profile Title

Research Investigator, Senior

Job Description Summary

The Senior Research Investigator will design, develop, implement, and maintain computational analysis tools for advanced fluorescence microscopy and super-resolution microscopy data. The position will be jointly based between the Lakadamyali Lab and the ACME core at the Perelman School of Medicine at the University of Pennsylvania, with an approximately 50/50 effort split between both groups. The Senior Research Investigator will, under limited supervision of Dr. Melike Lakadamyali and Dr. Mustafa Mir, lead independent software development and quantitative image analysis projects that support both fundamental biological research and core facility users across Penn.

Job Description

Job Description:

The Senior Research Investigator will build, validate, document, and deploy robust, custom-tailored and user-friendly image analysis pipelines for the analysis of super-resolution microscopy data, including but not limited to single-molecule localization microscopy, single-particle tracking, spatial statistics, and multi-dimensional image analysis. The successful candidate will work closely with the Lakadamyali Lab, ACME core leadership, Penn investigators, trainees, and collaborators.

The position requires an independent scientist with expertise in computational image analysis, microscopy, software development, and quantitative data interpretation. The successful candidate should have a highly analytical mindset and be able to identify analysis needs, design appropriate computational approaches, implement and test software tools, support the biological interpretation of imaging data, and help disseminate methods through publications, grants, and documentation.

Duties and Responsibilities:

• Design, build, validate, and maintain user-friendly software tools for the analysis of advanced fluorescence microscopy and super-resolution microscopy data for use by the Lakadamyali Lab, ACME core users, and collaborators.
• Develop analysis workflows for single-molecule localization microscopy, single-particle tracking, co-localization, spatial statistics, morpholomics analysis, and clustering.
• Perform quantitative analysis and interpretation of complex microscopy datasets generated from biological samples, including cells and tissues.
• Support, mentor, and train ACME core users by providing guidance on image analysis strategies, quantitative workflows, data interpretation, reproducible microscopy analysis practices, and tutorial development.
• Interface with wet-lab collaborators to translate biological needs into appropriate quantitative image analysis strategies.
• Write, test, optimize, and maintain code using appropriate programming and image analysis environments, including but not limite