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Senior Research Associate I, Discovery Cell Engineering (25029-B-670-PCP)
ArsenalBioSouth San Francisco, United Statesfull_timeVerifiedPosted 24 Feb 2025
💰 $83,300/yr
About the role
WHO WE AREArsenal Biosciences Inc. is a clinical-stage programmable cell therapy company engineering advanced CAR T-cell therapies for solid tumors. We seek a talented and experiencedSr. Research Associate I, Discovery Cell Engineering to work onsite based in our South San Francisco office.
ArsenalBio’s mission and purpose are very clear: defeat cancer. With our programmable and computationally driven approach, our team is engineering medicines to attack cancer’s inherent multifaceted nature and overcome the challenges of addressing solid tumors with cell therapy.
Driven by a collective of diverse experts across multi-scientific disciplines and clinical and manufacturing expertise, we are united in our purpose to develop the optimal medicines for improving patients’ lives.
This means you’ll have the opportunity to work with the best talent in the field of cell therapy and be part of ONE TEAM, which advances therapies for patients who need it most.
ArsenalBio is seeking a Senior Research Associate to support the T cell isolation and genome engineering and Cell line development cores as a part of our efforts to develop and commercialize curative immune cell therapies. This candidate will be responsible for optimizing and running cell isolations, designing and executing genome engineering workflows, and generating target cell lines. The ideal candidate will have experience with mammalian cell culture and experience with CRISPR-Cas9, lentiviral, and transposon based cell engineering methods. The candidate will be expected to coordinate with multiple teams across ArsenalBio to determine project needs and work within the Discovery team to identify and implement potential process improvements to optimize the workflow.
Our people-first culture cultivates a deep respect for humanity, not only in those we serve but also in one another. We take pride in being part of a company that values and celebrates diversity—in experiences, ideas, and interests. We are empowered in an environment that embraces unity and inclusivity, fostering a sense of belonging and mutual respect.
We provide powerful tools to empower our employees to take charge of their career paths and reach their full potential. At ArsenalBio, we believe in investing in our employees' well-being—both professionally and personally—because our people are our most valuable asset. Our essential team members bring exceptional expertise in molecular biology, immunology, pharmacology, protein chemistry, computational biology, automation, genome engineering, software, and other fields to turn the possibilities of tomorrow into the realities of today.
We are committed to h
ArsenalBio’s mission and purpose are very clear: defeat cancer. With our programmable and computationally driven approach, our team is engineering medicines to attack cancer’s inherent multifaceted nature and overcome the challenges of addressing solid tumors with cell therapy.
Driven by a collective of diverse experts across multi-scientific disciplines and clinical and manufacturing expertise, we are united in our purpose to develop the optimal medicines for improving patients’ lives.
This means you’ll have the opportunity to work with the best talent in the field of cell therapy and be part of ONE TEAM, which advances therapies for patients who need it most.
ArsenalBio is seeking a Senior Research Associate to support the T cell isolation and genome engineering and Cell line development cores as a part of our efforts to develop and commercialize curative immune cell therapies. This candidate will be responsible for optimizing and running cell isolations, designing and executing genome engineering workflows, and generating target cell lines. The ideal candidate will have experience with mammalian cell culture and experience with CRISPR-Cas9, lentiviral, and transposon based cell engineering methods. The candidate will be expected to coordinate with multiple teams across ArsenalBio to determine project needs and work within the Discovery team to identify and implement potential process improvements to optimize the workflow.
WHAT YOU’LL DO
- Conduct T cell isolation and processing to support company-wide requests
- Design and execute genome engineering studies to generate transgene expressing primary cells
- Fulfill cell line engineering requests including lentiviral and transposon-based gene editing
- Perform CRISPR-based gene knock-out
- Integrate and coordinate multiple different workflows into the cell isolation and genome engineering core activities
- Perform characterization of gene modified T cell populations and indication specific cell lines
- Troubleshoot and optimize experimental workflows
- Maintain detailed study logs of studies to facilitate datathe dissemination and reporting.
WHO YOU ARE
- Masters degree in biological discipline required with 0-2 years relevant experience, or Bachelors with 2+ years relevant experience Preferred Qualifications
- 2+ years of research experience with primary human T cell isolation/culture and multi-dimensional flow cytometry
- Experience in clinical scale cell processing (i.e. Miltenyi MultiMACS or equivalent platforms)
- Familiarity withwith electroporation technology is a plus
- Experience with automation platforms and databasing is desired
- Strong written and verbal communication skills
- Ability to acquire learn new skills and knowledge on the job, demonstrate productivity, and deliver high-quality results
- Technically minded with a strong aptitude for process optimization
- Excellent teamwork and collaboration skills
- Ability to multitask as needed in a fast-paced start-up environment
Our people-first culture cultivates a deep respect for humanity, not only in those we serve but also in one another. We take pride in being part of a company that values and celebrates diversity—in experiences, ideas, and interests. We are empowered in an environment that embraces unity and inclusivity, fostering a sense of belonging and mutual respect.
We provide powerful tools to empower our employees to take charge of their career paths and reach their full potential. At ArsenalBio, we believe in investing in our employees' well-being—both professionally and personally—because our people are our most valuable asset. Our essential team members bring exceptional expertise in molecular biology, immunology, pharmacology, protein chemistry, computational biology, automation, genome engineering, software, and other fields to turn the possibilities of tomorrow into the realities of today.
We are committed to h
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