Manager, Program Management

The Organization

What's happening at Entrada Therapeutics? Entrada is a clinical-stage biopharmaceutical company aiming to transform the lives of patients by establishing a new class of medicines that engage intracellular targets that have long been considered inaccessible. Through proprietary and versatile approaches, Entrada is advancing a robust development portfolio of genetic medicines for the potential treatment of neuromuscular and inherited retinal diseases, among others. Our lead oligonucleotide programs are in development for the potential treatment of people living with Duchenne muscular dystrophy (DMD) who are exon 44, 45, 50 and 51 skipping amenable. Entrada has partnered with Vertex Pharmaceuticals to develop a clinical-stage program, VX-670, for myotonic dystrophy type 1 (DM1).

2026 represents a catalyst-rich period for Entrada. We expect multiple clinical data readouts as we advance several DMD programs across the U.K., EU, and U.S. By year-end 2026, we anticipate four clinical-stage programs in our DMD franchise (ENTR-601-44, ENTR-601-45, ENTR-601-50, and ENTR-601-51). These programs are complemented by the ongoing clinical progress of our DM1 collaboration with Vertex (VX-670).

We are a tight-knit team of experts and leaders in both therapeutic development and rare diseases and are excited to grow and attract colleagues who are ready to join a high-energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The Perfect Addition to Our Team

You are excited about the opportunity to contribute to the growth of the program management function here at Entrada. You live in the details and enjoy connecting the dots of complicated development plans, but you are also interested in the strategy and science those details support. You welcome the opportunity to wear many hats and deepen your knowledge across functions. You work successfully in a fast-paced team environment and have strong interpersonal skills. You are a proactive communicator and are always willing to assist your team members in their shared goal of transforming the lives of patients.

The Opportunity

The Manager, Program Manager (PM) will provide comprehensive program management support across multiple clinical development programs, ensuring alignment with cross‑functional strategic and operational objectives. Success requires exceptional attention to detail, strong forward‑planning and organizational capabilities, and the ability to effectively engage, influence, and manage stakeholders across diverse teams.

Responsibilities

• Provide program management support to multiple clinical development project/program teams.
• Develop and maintain detailed end-to-end integrated program timelines; track and monitor key interdependencies and milestones.
• Support development of program meeting agendas and outcomes; document and track actions and decisions.
• Collaborate with cross-functional teams to ensure alignment with company and program objectives.
• Identify and track program risks, issues, and dependencies; ensure communication and awareness across key stakeholders.
• Apply PM best practices and methodologies to contribute to the growth and development of the Program Management Team.

The Necessities

At Entrada, our passion for science, our devotion to patients and our values drives our behavior:

• Humanity - We genuinely care about patients and about one another.
• Tenacity - We are relentless and persistent in the pursuit of developing therapies for patients.
• Creativity - We are creative problem solvers.
• Collaboration - We are more than the sum of our parts.
• Curiosity - We have a growth mindset and push conventional thought and theory.

To thrive on our team, you will need to come with:

• BA/BS degree required, with 8+ years in clinical and drug development within the biotech/pharmaceutical industry, with 3+ years in clinical-stage project/program management.
• Strong understanding of drug development and how various functions integrate.
• Proficiency in project management software (MS Project) and experience with timeline visualization software (e.g. OnePager).
• Excellent organizational skills and attention to detail.
• The ability to work effectively across functions.
• Ability to manage multiple priorities in a fast-paced, dynamic environment.
• Excellent verbal and written communication skills.
• Desire to work in an innovative and collaborative environment.
• PMP preferred but not required.
• This is a US based remote position, with preference given to local New England based candidates. This role will require regular on-site