Senior Scientist, Downstream

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

Position Summary

Join Bristol Myers Squibb's dynamic Manufacturing Sciences & Technology (MS&T) laboratory team, where you will play a critical role in supporting commercial manufacturing and process technology transfer for biopharmaceuticals. As a Senior Scientist specializing in downstream processes, you will contribute your expertise in purification and primary recovery within a diverse, highly technical, and collaborative team of scientists and engineers.

The successful candidate will act as a subject matter expert and key contributor to the MS&T organization. MS&T scientists and engineers work across functional teams to achieve high-impact business objectives and ensure robust, compliant, and efficient manufacturing operations. This position offers significant exposure to partner functions including Manufacturing, Manufacturing Technology, Bioprocess Development, Quality Assurance, Analytical, and Global Regulatory Sciences.

Key Responsibilities:

• Lead downstream process support for commercial manufacturing and technology transfer activities.

• Provide technical input for process investigations, including root cause analysis and implementation of corrective and preventive actions (CAPAs).

• Drive continuous improvement initiatives to enhance process robustness, efficiency, and compliance.

• Support downstream activities for technology transfer, process validation, and preparation of Chemistry, Manufacturing, and Controls (CMC) documentation.

• Contribute to regulatory filings and interface with regulatory agencies, including support for inspections and responses to inquiries.

• Design and execute technical studies to support manufacturing investigations or technology transfer of new processes. This includes leveraging laboratory and scale-down models for:

  • Protein chromatography

  • Viral inactivation

  • Viral filtration

  • Ultrafiltration/diafiltration

  • Membrane filtration

  • Depth filtration

  • Centrifugation

• Document and verify experimental data, interpret results in alignment with lab protocols and manufacturing processes, and generate comprehensive technical reports.

• Collaborate effectively with partners across MS&T, Manufacturing, Process Development, Quality, and Regulatory to align on technical strategies and execution.

• Evaluate emerging downstream process technologies and recommend improvements as appropriate.

• Demonstrate strong written and verbal communication skills to clearly convey technical data and conclusions.

Qualifications & Experience:

• Degree in Chemical/Biochemical Engineering, Biochemistry, or a related discipline:

  • BS with at least 7 years of relevant industry experience

  • MS with at least 5 years

  • Ph.D. with 2–4 years

• Strong scientific understanding of protein purification and stability.

• Proficiency with downstream processing equipment and techniques, including:

  • AKTA chromatography systems

  • Ultrafiltration/diafiltration systems

• Experience with viral clearance processes is preferred.

• Demonstrated scientific curiosity, critical thinking, and collaborative problem-solving.

• Effective communicator with strong technical writing skills.

• Ability to operate in a regulated environment with understanding of GMP manufacturing impact, though laboratory work is performed in a non-GMP setting.

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