Staff Scientist (Senior Manager), Reagent Manufacturing

About Glyphic:

At Glyphic Biotechnologies, we plan to create the protein revolution for which scientists and researchers have been waiting. We are developing a massively parallel, single-molecule proteome sequencing platform that will transform life science discovery and usher in a new era of insights into human biology and disease. To date, we have raised >$50M from venture partners and non-dilutive grant funding to achieve our vision of next generation proteome sequencing.

What we are looking for in you:

Glyphic is seeking an experienced reagent manufacturing leader who will report to the Chief Operating Officer and anchor a newly formed Reagent Manufacturing team focused on  standardizing and scaling-up Glyphic’s production and R&D reagents in support of a commercial launch. This will be a unique opportunity to define and run new manufacturing processes, build out a dedicated lab, and scale-up by 10-100X in a highly controlled environment.

The ideal candidate should have extensive experience in developing and executing production strategies to ensure long-term reagent supply and a proven ability to translate research protocols into a controlled production environment. 

The employee will need to be hands-on in designing and running plate-based manufacturing campaigns using automated liquid handling platforms in addition to liter-scale bulk reagent preparation. A successful candidate will need to work effectively with internal stakeholders (R&D, Product Development, Finance, Operations, Quality) and external vendors to meet current supply obligations and enable future roadmaps.  Experience in establishing new reagent manufacturing processes from protocol design to instrumentation selection/qualification in a controlled environment is highly desirable. 

Responsibilities:

• Perform complex reagent production protocols and comprehensive QC testing

• Track weekly reagent utilization and generate capacity/demand forecasts to ensure stable and reliable supply

• Manage end-to-end inventory system for raw materials and finished reagents

  • Order placement and delivery tracking

  • Minimum stock levels and order quantities

  • Raw material lead times

  • Expiration management

• Perform stability studies to determine shelf life and optimal environmental storage conditions

• Work with external vendors to implement long-term sourcing/supply agreements, evaluate alternative suppliers for critical reagents, and perform vendor qualifications

• Drive process optimization initiatives to reduce costs, increase production efficiency, and improve consistency

• Partner with R&D to define reagent specifications and requirements while ensuring that manufacturability, scalability, and cost are considered as part of all new reagent programs.

• Troubleshoot production issues, perform root cause analysis, and drive corrective actions

• Develop and maintain SOPs and BOMs for all Glyphic reagents

• Maintain detailed batch records and ensure quality/regulatory compliance

• Partner with QC to define, validate, and monitor material quality

Required Competencies:

• BS/MS in Biology, Chemistry, or a related field with a strong foundation in analytical chemistry (PhD preferred)

• 6+ years of reagent manufacturing experience with an emphasis on reagents required for protein and/or DNA synthesis & sequencing

• Extensive experience in solution preparation techniques and  analytical methodologies

• Experience running reagent quality control testing,  stability studies, and comparability programs

• Experience establishing and managing internal reagent manufacturing operations, external supply partnerships, and supply chains in support of new product launches

• Experience with Lean Manufacturing principles and process optimization

• Proven ability to support on-time customer order fulfillment while ensuring product quality requirements

• Strong background in process design, quality statistics, and structured problem-solving methodologies

• Experience with Lean Manufacturing principles and process optimization

• Strong documentation skills, including SOPs, batch records, and inventory management systems

• Preferred experience with DNA synthesis/purification

• Preferred experience with GLP/cGMP and ISO quality standards

• Preferred experience with automated liquid handling instrumentation

Benefits and Perks:

• Employee Stock Option Plan

• 100% Health Plan C