Senior Scientist I, siRNA in vitro Biology

Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.

Job Description

At AbbVie, we are dedicated to solving some of the world’s most complex and serious diseases. Within AbbVie’s Biotherapeutics and Genetic Medicine (BGM) organization, our siRNA team is advancing therapeutic programs from early discovery through development, applying rigorous biology and data-driven decision making to build differentiated RNA medicines.

AbbVie is seeking a Senior Scientist I with deep, hands-on expertise in siRNA therapeutic discovery to join the siRNA group within Biotherapeutics and Genetic Medicine (BGM). This role will involve designing and executing innovative experimental approaches to address key scientific challenges related to oligonucleotide therapeutics. The successful candidate will drive scientific innovation, identify new methods and techniques, and collaborate across functions to support the development of novel RNA-based therapies.

This role is best suited for candidates with direct, hands-on experience in therapeutic siRNA discovery, where siRNA biology directly informed experimental and program-level decisions.

Responsibilities

• Independently lead in vitro siRNA discovery biology, including experimental strategy, assay design, execution, data analysis, and interpretation in support of active therapeutic programs.
• Design, optimize, and validate fit-for-purpose assays that directly inform siRNA potency, durability, specificity, and mechanism-of-action.
• Drive scientific decision making by integrating siRNA knockdown data with orthogonal readouts (protein, functional, and transcriptomic endpoints).
• Identify and resolve key biological and technical risks related to siRNA activity, delivery, and on-target effects.
• Work with cros