Executive Director, Commercial Enablement

Company Overview

Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted therapies designed to improve outcomes for cancer patients. We are advancing an innovative portfolio of therapeutics, drawing on leadership that previously played key roles in the design, development, and commercialization of cutting-edge targeted cancer therapies, including antibody-drug conjugate therapies (ADCs). Our most advanced pipeline programs are varegacestat (formerly AL102), a gamma secretase inhibitor which is currently in a Phase 3 trial for treatment of desmoid tumors; IM-1021, a ROR1-targeted ADC which is currently in a Phase 1 trial; and IM-3050, a FAP-targeted radioligand, which recently received IND clearance. Our pipeline also includes IM-1617, IM-1335, and IM-1340, all of which are preclinical ADCs pursuing undisclosed targets with expression in multiple solid tumors.

Position Overview

Commercial Operations serves as the executional backbone for Immunome’s oncology launch—connecting field readiness, data infrastructure, supply continuity, and compliance excellence under a single operational leader. Executive Director, Commercial Enablement leads the integration of systems, data, and processes that enable commercial readiness, launch excellence, and operational scalability. This leader partners across functions to ensure disciplined execution, performance management, and compliant commercialization.

Responsibilities

Commercial Enablement & Field Operations:

• Design and implement field force structure (Sales, MDM, Market Access).
• Manage targeting, segmentation, and call-plan alignment.
• Oversee national and regional meetings / POAs (content, logistics, execution).
• Direct incentive compensation plan design, quota setting, and payout governance.
• Drive commercialization governance including CLT/SteerCo cadence, readiness dashboards, and risk management.
• Manage commercial vendors and budget portfolios across functions.

Supply Chain & Distribution:

• Develop channel strategy and network design.
• Lead SP/SD partner selection, contracting, and performance management (KPIs, SLAs, scorecards).
• Ensure seamless order fulfillment, reconciliation, and product traceability.
• Leverage distribution data and analytics to inform dashboards and field execution.
• Collaborate with Market Access, Patient Services, Finance, Regulatory, Quality, Compliance, and Medical Affairs.

Training & Field Development:

• Establish onboarding, certification, and continuous learning programs for Sales and Medical field teams.
• Build coaching frameworks, curriculum design, and field manager toolkits.
• Implement role-based learning pathways (Sales, MSLs, FRMs, HQ).
• Partner with Medical and Compliance to ensure compliant communications and content.

CRM, Data & Analytics Enablement:

• Administer and govern CRM platforms (Veeva/SFDC) ensuring design integrity, data hygiene, and change control.
• Oversee master data management (HCP/HCO) and integration into commercial data lake architecture.
• Deliver field performance dashboards, KPI tracking, and standardized QBR reporting.
• Ensure IC data pipelines support audit readiness and transparency.
• Compliance, Quality & Governance:
• Coordinate aggregate spend and transparency reporting workflows with Compliance.
• Oversee AE/PQC reporting in partnership with Safety/Quality.
• Maintain field conduct SOPs, audit readiness, and monitoring processes.
• Partner with Legal, Quality, and Compliance to uphold governance standards.

Qualifications

• Bachelor’s degree required; advanced degree preferred.
• A minimum of 10+ years in commercial operations, field enablement, supply chain, or analytics within biopharma; oncology launch experience preferred.
• Proven track record leading cross-functional commercial readiness initiatives.
• Experience managing SP/SD relationships and vendor performance metrics.
• Familiarity with CRM (Veeva/SFDC), MDM, and commercial data architecture governance.

Knowledge and Skills

• Proficiency in CRM (Veeva/SFDC), data visualization, and dashboarding tools.
• Strong analytical and problem-solving skills with ability to translate data into field action.
• Demonstrated excellence in cross-functional leadership and communication.
• Deep understanding of commercial operations, governance, and launch readiness processes.
• Experience managing vendor