Principal Scientist- Downstream Process Development

ROLE SUMMARY:

As a Principal Scientist Downstream R&D you will contribute to downstream process development for various vaccine programs. You will work closely with the Senior Principal Scientist/Director to develop and apply interdisciplinary approaches to improve purification and characterization of the mRNA Drug Substance (DS) for the development of next-generation RNA vaccine candidates. You will be recognized as a technical expert and a significant scientific contributor. With your deep knowledge of the discipline, you will regularly contribute at the vaccine development meetings and can represent the department on multidisciplinary teams. You will also undertake mentoring activities to guide team members. With your innovative scientific acumen, you will apply cutting edge design and process development capabilities to accelerate and bring the best-in-class mRNA-based vaccines to patients around the world.

POSITION RESPONSIBILITIES

• Lead the multi-step design, planning and execution of analytical strategies, methods and instrumentation to purify and characterize the mRNA Drug Substance (DS).

• Develop continuous downstream process for drug substance.

• Mentor junior scientists’ research activities and provide technical guidance when necessary.

• Collaborates with colleagues and subject matter experts to assess the most appropriate analytical approach to support project activities, including use of computational predictive tools, modelling software and data visualization tools where appropriate.

• Through effective leadership, communication and collaboration with multidisciplinary team members, this colleague will have the opportunity to lead and be responsible for several projects, helping teams devise effective strategies for analytical requirements and controls.

• The candidate must collaborate with, mentor peers, and effectively interact with colleagues at all levels of the organization.

• Author relevant sections of vaccine technical report documents in support for interdepartmental technology and method transfer. They will also prepare technical reports, critically review data, and may evaluate new instrumentation and analytical techniques/approaches.

• Proficient with a wide variety of software and information systems and the curiosity and passion to continue learning in a dynamic environment.

ORGANIZATIONAL RELATIONSHIPS

• This colleague will interact with Bioprocess Fermentation, Analytical, and Formulation Development groups to support downstream process development and in-process sample analysis activities.

RESOURCES MANAGED

Financial Accountability

• The incumbent advises the supervisor of the equipment and consumables required to accomplish the work.

Supervision

• The incumbent will have supervisory responsibilities.

EDUCATION AND EXPERIENCE

• PhD degree in